DD-597Sciencealso PeopleFiled Last updated

Sclerotherapy

Short answer: Sclerotherapy treats unwanted veins by injecting a solution (a sclerosant) that damages the vein's inner lining, the endothelium. The vein then becomes inflamed, scars and closes, and over weeks to months the body clears it and it fades.

It's used for spider veins (telangiectasias), small reticular veins and some varicose veins. For larger varicose veins, the sclerosant is often whipped into a foam and injected under ultrasound guidance, a technique NICE has assessed in its guidance. The sclerosants in widest use are detergents such as polidocanol and sodium tetradecyl sulfate, which break down the cell membranes of the lining. Hypertonic saline, a concentrated salt solution, works by drawing water out of the cells. It's one option, but not the usual one, and ordinary saline wouldn't close a vein. Several sessions may be needed. Clinical sources list common effects such as pain at the injection site, bruising, temporary lumps, brown staining of the skin and new tiny red veins ('matting'). They list rare complications including skin ulcers, allergic reactions, and clots in deeper veins. This case is general information, not medical advice. The footage shows a needle injecting into small purple veins on a leg.

VideoWrite-up5 sources

In collections:Inside the Body

What should you know about Sclerotherapy?

Quick facts. Each one stands alone and has a stable ID you can cite.

  1. Sclerotherapy closes veins by damaging their lining.

    DD-597-F01 · Write-up · Exhibit A (Damage on purpose)
  2. Polidocanol is a detergent-type sclerosant.

    DD-597-F02 · Write-up · Exhibit A (Damage on purpose)

Video transcript: Sclerotherapy: Closing Veins From the Inside

DID YOU KNOW? Vascular sclerotherapy is a medical procedure used to treat varicose and spider veins. A sclerosing agent, typically a saline solution or chemical like polidocanol, is injected directly into the affected vein. This irritates the vein's inner lining, causing endothelial damage and inflammation. The vein collapses, forms scar tissue, and is gradually reabsorbed by the body. NOW YOU KNOW!

Burned-in captions, read frame by frame (see transcript.md) · 20.7s Reel ·

Video coming soonSclerotherapy · Instagram Reel
Sclerotherapy: Closing Veins From the Inside Instagram Reel · · 20.7s

The write-up

Closing veins from the inside. Sclerotherapy injects a solution that seals small veins shut.

  1. Exhibit A

    Damage on purpose

    A sclerosant injures the vein's inner lining, so the vein scars, closes and fades.

  2. Exhibit B

    Detergents lead

    Polidocanol and sodium tetradecyl sulfate are detergents that break down the lining's cells.

  3. Exhibit C

    Salt is the alternative

    Hypertonic saline works by drawing water out of the lining's cells.

  4. Exhibit D

    Foam for bigger veins

    For larger varicose veins, sclerosant foam is injected under ultrasound guidance.

  5. Exhibit E

    Known side effects

    Clinical sources list bruising, staining and new tiny veins, and rarely ulcers or clots.

Questions people ask about Sclerotherapy

What does a sclerosant damage?

The endothelium.

Source: Write-up · Exhibit A (Damage on purpose) · StatPearls (NCBI Bookshelf): Sclerotherapy; DermNet: Sclerotherapy

What kind of agent is polidocanol?

It breaks down the lining's cell membranes.

Source: Write-up · Exhibit B (Detergents lead) · StatPearls (NCBI Bookshelf): Sclerotherapy; Sclerotherapy for lower limb telangiectasias, Cochrane review (PMC)

How does hypertonic saline work?

Osmotic injury.

Source: Write-up · Exhibit C (Salt is the alternative) · StatPearls (NCBI Bookshelf): Sclerotherapy; Sclerotherapy for lower limb telangiectasias, Cochrane review (PMC)

How are larger varicose veins often treated with sclerotherapy?

As assessed in NICE guidance.

Source: Write-up · Exhibit D (Foam for bigger veins) · NICE HTG301: Ultrasound-guided foam sclerotherapy for varicose veins, the procedure

Which side effect do clinical sources list?

Along with bruising and new tiny veins.

Source: Write-up · Exhibit E (Known side effects) · DermNet: Sclerotherapy; Cleveland Clinic: Sclerotherapy

Test Your Knowledge

All quizzes →

5 questions, all from this case file. Answers are revealed instantly.

  1. What does a sclerosant damage?

    1. The vein's inner lining
    2. The skin's surface
    3. The bone
    4. The nerve
    Show the answer

    Answer: A. The vein's inner lining The endothelium. Source: Write-up · Exhibit A (Damage on purpose) · StatPearls (NCBI Bookshelf): Sclerotherapy; DermNet: Sclerotherapy

  2. What kind of agent is polidocanol?

    1. A detergent
    2. An antibiotic
    3. A painkiller
    4. A vitamin
    Show the answer

    Answer: A. A detergent It breaks down the lining's cell membranes. Source: Write-up · Exhibit B (Detergents lead) · StatPearls (NCBI Bookshelf): Sclerotherapy; Sclerotherapy for lower limb telangiectasias, Cochrane review (PMC)

  3. How does hypertonic saline work?

    1. It draws water out of the lining's cells
    2. It freezes the vein
    3. It heats the vein
    4. It dissolves blood
    Show the answer

    Answer: A. It draws water out of the lining's cells Osmotic injury. Source: Write-up · Exhibit C (Salt is the alternative) · StatPearls (NCBI Bookshelf): Sclerotherapy; Sclerotherapy for lower limb telangiectasias, Cochrane review (PMC)

  4. How are larger varicose veins often treated with sclerotherapy?

    1. Foam under ultrasound guidance
    2. Oral tablets
    3. A cream
    4. Massage
    Show the answer

    Answer: A. Foam under ultrasound guidance As assessed in NICE guidance. Source: Write-up · Exhibit D (Foam for bigger veins) · NICE HTG301: Ultrasound-guided foam sclerotherapy for varicose veins, the procedure

  5. Which side effect do clinical sources list?

    1. Brown staining of the skin
    2. Hair loss everywhere
    3. Blue eyes
    4. Hiccups
    Show the answer

    Answer: A. Brown staining of the skin Along with bruising and new tiny veins. Source: Write-up · Exhibit E (Known side effects) · DermNet: Sclerotherapy; Cleveland Clinic: Sclerotherapy

Cite this case file

Easterling, Marcus. "Sclerotherapy." The Detail Department (DetailEnjoyer), case file DD-597, last updated Jun 16, 2025. https://detailenjoyer.com/case/sclerotherapy/

Permalink: https://detailenjoyer.com/case/sclerotherapy/ · Last updated

Markdown version

Cite a single fact by its ID, for example DD-597-F01 → https://detailenjoyer.com/case/sclerotherapy/#DD-597-F01